Expression and clinicopathological significance of human growth and transformation-dependent protein (HGTD-P) in uterine cervical cancer

Sir: Cervical cancer is the second most common malignancy in women worldwide. In developing countries, most cases are still diagnosed with locally advanced disease, so the great challenge in the management of advanced cervical cancer remains the control and prevention of distant metastasis. A prominent feature of clinically advanced cervical cancers is hypoxia which is, therefore, a therapeutic and prognostic factor associated with radio-resistance and worsened clinical outcome. A central coordinator of the hypoxic cellular response is hypoxia-inducible factor-1a (HIF-1a), a master transcription factor regulating the expression of numerous downstream targets. HIF-1a binding to hypoxia response elements at